Although it has pretty flowers and is available in several different cultivars that work well in landscaping, it can also make quite a nuisance of itself through rampant spread. Alternatively, some formulas contain (Panax pseudoginseng or Radix notoginseng), and variously Chinese yam (Dioscorea opposita), yam rhizome (Dioscorea hypolglauca), sweet geranium (Erodium stephanianum), and galangal rhizome (Alpinia officinarum) (Polesuk 1973). The anti-adipogenic potential was validated in human mesenchymal stem cells and murine mesenchymal cell-line C3H10T1/2. This name is a synonym of Ajuga integrifolia Buch.-Ham.. Further molecular docking studies using FlexX program demonstrated that it docked well into the same pocket that accommodates statin inhibitors. They are perennial or annual herbs with opposite leaves. The toxicological effects of A. iva were scarcely explored. Suriya P. Singh, Koneni V. Sashidhara, in European Journal of Medicinal Chemistry, 2017. The plant extract may reduce intestinal cholesterol absorption. (2.4) and obacunone from Dictamnus dasycarpus Turcz. canescens (Benth.) 2007, Lipid lowering agents of natural origin: An account of some promising chemotypes, Suriya P. Singh, Koneni V. Sashidhara, in, A review of Algerian medicinal plants used in the treatment of diabetes, Toxicological Survey of African Medicinal Plants, Bjugamacrin B, ajugacumbin A, ajugatakasin A, ajugacumbin B, ent-3β-(3-methyl-2-butenoyl)oxy-15-beyeren-19-oic acid. The record derives from WCSP (data supplied on 2012-03-23 ) which reports it as a synonym (record 5380) with original publication details: Pl. How to say Ajuga reptans in English? On the other hand, the Old English Herbarium advises that betony is effective by causing a vomiting up of the poison taken if the herb and root to the weight of three coins is decocted in 4 cups of wine and drunk down. ex Vatke =Ajuga remota Benth. The volatile oils of eight species of Stachys growing in Greece were tested against six bacteria and five fungi, and Stachys scardica was the most effective, but, as in many studies, no oil inhibited growth of Pseudomonas aeruginosa (Skaltsa et al 2003). ex Vatke) Baker =*Ajuga remota var. Later, Imamura et al. The most active extract was from Ajuga iva.300 In the same study, 35 neo-clerodanes were tested, and 16 were significantly active with S. littoralis and 13 with S. frugiperda, but there was no correlation between plant activity and their content of known clerodanes.300 This study also showed how antifeedant activity changes from month to month, with maxima in April and October for Teucrium polium and in May and October for Ajuga reptans.300, Clerodanes are antifeedants for a large number of species, especially among the Lepidoptera, but they are feeding stimulants for the turnip sawfly (Athalia rosae, Hymenoptera). These same authors cite another use from Musa, of a decoction of the roots and powdered herb applied externally to a painful, gouty joint. crenata (Hochst. The blockade of nuclear factor NF–κB results from the hypophosphorylation of nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor α (IκBα) as upstream effectors such as the kappa light polypeptide gene enhancer in B-cells inhibitor (IκB) kinase (IKK) which are targeted by terpenes. Although several approaches have been reported for the synthesis of clerodane and related diterpenes [241–243], but only three describe the synthesis of 40. Ajuga iva (L.) Schreb. Cornutin A was slightly more active.347 Kolavenol (191), originally from Melompodium divaricatum, but found in many other sources, is very weakly active against feeding (5500 ppm gave a reduction to one-third pick-up in the test above) by another leaf-cutting ant, Atta cepholotes, but is not toxic to them or their mutualistic fungus.348,349 The four compounds (192)–(195) from Detarium microcarpum are claimed to show strong antifeedant activity at 1% against the termite Reticulitermes speratus in a paper disk assay.350 Activity may not be high, but antifeedancy against termites is interesting. Copyright © 2020 Elsevier B.V. or its licensors or contributors. Treatment and control of malaria have become more difficult with the spread of drug-resistant parasites and insecticide-resistant mosquito vectors. Cultivars of this species feature leaves with more interesting and varied foliage color. The comparative antifeedant effects of several nonalkaloidal and alkaloidal ryanoids supported the hypothesis of a ryanodol-specific mode of action in insects.64,67 The insect-selective insecticidal and antifeedant effects of ryanodanes hold a promising future for their use as biopesticides. This proprietary Chinese formula is said to be composed of Panax notoginseng, San Yu Cao (Ajuga patantha), Dioscorea opposita, Chuan Shan Long (Dioscorea nipponica), Lao Guan Cao (Erodium stephanianum), Alpinia officinarum, Bai Niu Dan, and Dryobalanops aromatica (or Blumea balsamifera) (package label, 2005). The FlexX docking scores were found to be better than lovastatin showing that binding interaction of its conformations with the protein residues were superior to lovastatin [247]. canescens (Benth.)Engl. Definition of ajuga remota is አቆራራጭ፣ አርማጉሳ. crenata Hochst. The activity profile shown by 40 was much better than the standard drug lovastatin at the same testing dose. In Morocco and Algeria, this plant is used in traditional medicine against several diseases especially diabetes (Bellakhdar et al., 1991; Ziyyat et al., 1997; Merzouki et al., 2000; Jouad et al., 2001; El-Hilaly et al., 2003; Tahraoui et al., 2007; Allali et al., 2008; Kemassi et al., 2014; Telli et al., 2016; Youbi et al., 2016; Barkaoui et al., 2017). It is also used for other indications, such as vasorelaxant (El-Hilaly et al., 2004), hypolipidemic (El-Hilaly et al., 2006), and anti-inflammatory, antifungal, antimicrobial, antifebrile, anthelmintic and antifeedant (Bondi et al., 2000). It has Ajuga remota (wanjiru wa ruriî) touted as a covid and malaria cure, dandelion for cancer, and many more. crenata (Hochst. 8-O-Acetylharpagide, isolated for the first time from the east African A. remota, did not exhibit any antiplasmodial activity even at the highest concentration of about 500 µM used against the chloroquines-sensitive strain of P. falciparium (FCA20/GHA). With this study clerodane diterpene emerged as a new class of lipid lowering agent which acts through the inhibition of HMGR as one of the probable mechanistic pathway. The insect antifeedant property of clerodane diterpenes is the most extensively studied bioactivity of these compounds.59 Scutellaria and Ajuga genera (Lamiaceae) produce some of the most potent clerodane antifeedants. aqueous extract improves the antioxidant status by reducing lipid peroxidation, oxidative stress and enhancing the antioxidant enzymes activities in plasma, erythrocytes and tissues of diabetic rats (Bouderbala et al., 2008, 2010; Chenni et al., 2007; Taleb-Senouci et al., 2009). Although numerous studies confirmed the pharmacological effects of A. iva and its compounds, at the best of our knowledge, no review was published to critically highlight these results and suggest the future potential clinical applications of this plant. This plant belongs to the family of Labiatae or Lamiaceae, its vernacular name in Algeria is “Chendgoura” or “Chendghoura” (Boudjelal et al., 2015; Miara et al., 2013) or “Toutoulba” (Kemassi et al., 2014) as named in North-eastern Sahara. Ajuga remota in particular is traditionally used as a herbal remedy for fever and infections, and is prescribed for malaria by 66% of the Kenyan herbalists. Conservatoire et Jardin botaniques de la Ville de Genève. Ajuga ( / ə ˈ dʒ uː É¡ ə /), [3] also known as Bugleweed, [4] Ground pine [5] or Carpet bugle, is a genus of about 40–50 species of annual and perennial herbaceous flowering plants in the mint family Lamiaceae, with most species native to Europe, Asia, [6] and Africa, but also two species in southeastern Australia. We use cookies to help provide and enhance our service and tailor content and ads. Additionally, it ameliorated obesity, impaired glucose tolerance, weight gain and other lipid parameters in obese C57BL/6 mice [240]. (0.05, 0.10, 0.15 mg/kg BW), extracts were given orally for three weeks. Later, it has been frequently reported from the genus Polyalthia and also from other plant sources [230–234]. Compounds from Plocamium suhrii were tested for their in vitro antiproliferative effects against WHCO1 esophageal cancer cells using the MTT assay. This lower activity of compounds with CO compared with CH2OH seems to be fairly common among the diterpenes. There are 40 to 45 species found throughout almost the whole world. In conclusion, we can agree with Tyler that betony has been proposed for virtually any disease conceived of, certainly up to Culpeper's time. ex Vatke : Synonym(s) Heterotypic =Ajuga remota Benth. Plants observed not to be taken by raids of the leaf-cutter Acromyrmex octospinosus in Panama were selected. It is an herbaceous flowering plant, in the mint family, native to Europe. However, when microglial cells are chronically activated by β-amyloid peptides during Alzheimer’s disease (AD) or α-synuclein during Parkinson’s disease (PD), these cells release cytokines which are neurotoxic. It appears only in those authors drawing from Musa, here Dalechamps, Bauhin, the Old English Herbarium, the Salernitan herbal and Parkinson, who sources Bauhin. Several genera from the Verbenaceae and Lamiaceae families have been identified as rich sources of neoclerodane diterpenoids. Its two known isolates ajugarin-1 and ergosterol-5,8-endoperoxide and a new isolate 8- O -acetylharpagide were evaluated for their in vitro antiplasmodial activity. Examples of neuroprotective terpenes from medicinal plants are thymoquinone from Monarda didyma L. (2.1), bilobalide from Ginkgo biloba L. (2.2), isoatriplicolide tiglate from Paulownia tomentosa (Thunb.) For this condition, Menzies-Trull wants it prescribed with skullcap Scutellaria lateriflora and black cohosh Cimicifuga racemosa. Human translations with examples: ajuga, bugle, ajugas, bugles, ajuga l, ajuga reptans. Identifying lead molecules from natural products might help to find better anti-malarial drugs, since those obtained from natural sources are still effective against malarial parasites. Therefore, any agents able to assuage neuro-inflammation may be first line candidates for the treatment of AD, PD and Amyotrophic Lateral Sclerosis (ALS) and such agents may very well be found among the terpenes engineered by medicinal plants such citronellol from Pelargonium graveolens L’Hér. Most of the tests are with Spodoptera species. Item Preview remove-circle Share or Embed This Item. Michel Kenne Tchimene, ... Victor Kuete, in Medicinal Plant Research in Africa, 2013. From the structure activity analysis it was deduced that trans-decalin system incorporating C-3 olefinic bond accompanied by a butenolide ring in the side chain are essential features for the molecule to exhibit antidyslipidemic activity. (1995) described the first total synthesis of 40 starting from an enantiomerically pure decalone [244]. Ajuga integrifolia has a wide native range, from northeast Africa, through Arabia, temperate and tropical Asia to New Guinea. Ajuga remota Benth. Macer mentions cough only. Betony, along with white horehound Marrubium vulgare, showed itself the strongest of the plants tested in inhibiting lipid oxidation. ajuga. canescens (Benth.) Ajuga (zhivuchka in Russian), a genus of plants of the family Labiatae. Copyright © 2011 Published by Elsevier GmbH, https://doi.org/10.1016/j.phymed.2011.08.063. The respiratory tract is in fact another body system for which betony is recorded as having uses. Musa proposes betony for the treatment of intermittent malarial fevers and continual fevers, but Dioscorides makes no such proposal nor that of the plant bruised with salt and placed in the nostrils for nosebleed. In vitro pharmacological studies have been conducted on constituents of A. remota of which some of them displayed a concentration-dependent inhibition of chloroquine-sensitive and -resistant Plasmodium falciparum and Mycobacterium tuberculosis. 16α-hydroxycleroda-3, 13 (14) Z-dien-15, 16-olide (40) is a hydroxybutenolide clerodane diterpene which was first isolated and characterized from Polyalthia longifolia [229]. None of these points is listed in the Old English Herbarium. was tested in alloxan rat models (150 mg/kg BW) (Chabane et al., 2013). Ryanodane diterpenes are compounds that are structurally related to the known insecticide ryanodine (see Section3.09.2.10). Define genus Ajuga. It is also used in Morocco to treat other illnesses such as rheumatic pains, hypertension, cardiovascular disorders, ocular infection, rheumatism, allergy, cancer, renal diseases, and digestive disorders (El Rhaffari and Zaid, 2002; El Amrani et al., 2010; Ghourri et al., 2013; Benkhnigue et al., 2014; Jamila and Mostafa, 2014; Hachi et al., 2015; Orch et al., 2015; Slimani et al., 2016; Youbi et al., 2016; Bouyahya et al., 2017). Studies have shown antioxidant activity in a range of Stachys species and found a correlation with the concentration of polyphenols (Háznagy-Radnai et al 2006, Matkowski & Piotrowska 2006, Khanavi et al 2009) although Vundać et al (2007) argue that only the scavenging of free radicals is significant. There are two pharmacological studies (Boudjelal et al., 2015; Chabane et al., 2013). This time Serapio repeats the use as well, as does Miller in the 18th century alongside rheumatism, for which conditions a diet drink of betony, wood sage (the hepatotoxic Teucrium scorodonia) and ground-pine Ajuga chamaepitys was recommended. In a recent study, 40 was shown to be the major active constituent of P. longifolia, responsible for its lipid lowering properties by us. Select a category... Ajuga Trustees Checklist Internet Governing Board Crowns Knowledge Bases Soil Fungi Water Supply Plant Leaves Nurseries Schools, Nursery Harmful Algal Bloom Flowers Nurseries, Hospital Cacao Dictionaries, Medical Dictionaries as Topic Dictionaries, Chemical Dictionary Terminology as Topic Dictionaries, Pharmaceutic Potentilla … f. (2.3), and asiatic acid from Centella asiatica (L.) Urb. Dioscorides too notes the use of betony for bites of wild animals, as does Galen, but the former also countenances the herb neutralizing deadly poisons. Noun 1. genus Ajuga ... Ajuga remota benth. The expressed juice of the leaves or the pounded leaves macerated in water eases pains in the ears if inserted lukewarm after being mixed with rose-oil. Internally, 1 drachm (4 g) of the leaves infused in 4 cyathi (180 mL) of hot water draws down through the lower organs that blood whose vapours rise back to pour into the eyes while the leaves of this herb eaten will sharpen the sight. Table 4. Applied with salt, it can heal sinuous and burrowing ulcers. (2.4)., deoxygedunin from Azadirachta indica A. Juss. However, the compound exhibited in vitro cytotoxicity against the A431 human skin carcinoma cell line. Learn the translation for ‘ajuga’ in LEO’s English ⇔ German dictionary. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Insecticidal diterpenes for the period 2006–08 (in part), E. David Morgan, Ian D. Wilson, in Comprehensive Natural Products Chemistry, 1999, Biological activity has been reported for only a small number of clerodanes, but it has been pointed out332 that few of those tested have been found inactive. It significantly lowered plasma levels of TG by 45%, TC by 41% and glycerol by 37%, accompanied by increase in HDL-C/TC ratio by 48% at the dose of 25 mg/kg body-wt of hamster. In feeding bioassays with Spodoptera litura, 3.6 ppm of clerodin causes 50% inhibition of feeding, and with Spodoptera littoralis 50 ppm causes complete inhibition,337 but the greatest single species activity listed is for the compound ajugarin I (179),338 with 80–100% feeding inhibition for Schistocerca gregaria at 0.06 ppm. Diterpene 40 has been reported to show significant biological activities such as antifeedant, antimicrobial, antimalarial, and cytotoxicity against various human cancer cell lines [229,233,235–238]. However, to the best of our knowledge, these studies did not report the molecular targets implicated in A. iva pharmacological effects. The leaves of the ajuga hold close together, which keeps them nice and short. (1830) =Ajuga bracteosa var. We use cookies to help provide and enhance our service and tailor content and ads. They were obtained from the leaves of Ajuga remota (Labiatae), with ajugarin I in 0.05% yield. These may have some relevance to the differential diagnosis and treatment of head pain and sinusitis. Mixed with sheep fat to form an ointment, the herb heals carbuncles. Bulga Kuntze. The docking analysis revealed that Ergosterol 5,8 endoperoxide derived from Ajuga remota, have the best binding interaction with protein targets compared with other ingredients and standard drugs. Ajuga remota in particular is traditionally used as a herbal remedy for fever and infections, and is prescribed for malaria by 66% of the Kenyan herbalists. Gerard recommends it for worms. (Labiatae) two compounds, jodrellins A (185) (0.005% of dry weight of plant) and B (186) (0.023% by weight, also in S. galericulata), which are the most active clerodane antifeedants isolated so far.340 The extra C-2 to C-19 oxygen link seems to increase the antifeedant activity of the jodrellins relative to clerodin. Diterpene 40 reduced expression levels of GLUT4, PPARγ and C/EBPα and also reduced Akt/mTOR phosphorylation thereby strongly inhibited the factors responsible for early differentiation of adipocytes. K. Cocquyt, ... G. Laekeman, in Phytomedicine, 2011. Some bioactive monoterpenes identified in African medicinal plants. Finally, there is a range of external uses to which betony has been put. Betony in an eclegma, or thick syrup made from honey, sometimes conveyed to the mouth on a root of liquorice which is licked clean, and taken for 9 days eases a cough. : From ethnopharmacology to phytomedical perspective in the treatment of malaria, Israili and Lyoussi 2009; Ramazanov 2005; Rharrabe et al. However, its use has not been scientifically validated. Ajuga remota is the most frequently used medicinal herb for malaria treatment in Kenya. Galen states that betony cleanses the lungs and Serapio repeats this, adding a strengthening action. The biological activity of clerodanes from a range of species of Baccharis (Compositae), Teucrium (Labiatae), and Salvia (Labiatae) has been examined but without finding any exceptionally active compounds.345, In a systematic search of the Labiatae using feeding bioassays on S. littoralis and S. frugiperda, of 24 species of Teucrium (out of 100 known species), 25% showed activity against S. littoralis, and all nine species of Ajuga were active. =Ajuga remota var. 1: 59 1830. It grows in tropical lowland areas (Indonesia) and also at elevations up to 1,600 metres (Philippines), whilst in Nepal it can be found up to 4,000 metres. In this study, rats were divided into six groups: control normal group, diabetic control, diabetic rats treated with glibenclamide, diabetic rats treated with Ajuga iva (L.) Schreb. Clerodane diterpenes are an important diverse class of secondary metabolites characterized by a bicyclic decalin ring system. canescens (Benth.)Cufod. Several ryanodane diterpenes, including ryanodol, cinnzeylanol, cinnzeylanone, and cinnzeylanine, have been isolated from the Macaronesian paleoendemism Persea indica (Lauraceae).64,65 Ryanodol and didehydroryanodol, in contrast to ryanodine and didehydroryanodine, have low toxicity to mice and limited activity at the mammalian ryanodine receptor but are potent knockdown agents for injected houseflies or cockroaches, suggesting a possible difference in the target sites of mammals and insects.66 The antifeedant activity of these compounds has been evaluated, showing the importance of the 11-hemiketal group for the antifeedant effects of ryanodane diterpenes. In light of this, Chapter 3 proposes several plant terpenes for thymoquinone, (2R)-hydroxyneomajucin, ajugaciliatin B, and 11-keto-β-boswellic acid are sources of synthetic derivatives alkaloids for the treatment of these neurodegenerative diseases. English Keyword (fr) Activité biologique Antipaludique Antiparasitaire In vitro Médecine traditionnelle Origine végétale Pharmacognosie Plante médicinale Plasmodium falciparum Ajuga remota Caesalpinia volkensii Caesalpiniaceae Kenya Angiospermae Apicomplexa Dicotyledones Labiatae Protozoa Spermatophyta Afrique Keyword (en) Translation of አርማጉሳ in English. On the other hand, a beneficial effect of ecdysteroids is improvement of silk yield by feeding 20-hydroxyecdysone (4) to silkworm (Israili and Lyoussi 2009; Rharrabe et al. Although the compounds tested here were significantly less active than the standard drug chloroquine (IC50 of 0.036 µM), it is interesting to note that (3R*,4S*,5E,7Z)-3,4,-dichloro-7-(dichloromethyl)-3-methylocta-1,5,7-triene and (3R*,4S*,5E,7Z)-3,4,8-trichloro-7-(dichloromethyl)-3-methylocta-1,5,7-triene containing the 7-dichloromethyl moiety were the most active (IC50 of 16 and 17 µM, respectively) [79] (Table 1.1). Other compounds showing exceptional activity were ajugapitin (184) from Ajuga chamaepitys (Labiatae) and 4,15-dihydroajugapitin from Ajuga pseudoiva, both of which were active at 0.3 ppm against S. littoralis.339 Clerodin and dihydroclerodin are both active at 50 ppm against S. littoralis. Translation of ajuga remota in Amharic. In Scutellaria, jodrellin B (occurring in S. albida, S. galericulata, S. grossa, S. polyodon, and S. woronowii) and scutecyprol B (found in S. columnae, S. cypria, S. grossa, and S. rubicunda) exhibit the highest antifeedant index against S. littoralis.60,61 From Ajuga pseudoiva leaves, 14,15-dihydro-ajugapitin displayed the highest activity.62 Furthermore, the genus Teucrium is one of the richest sources of clerodane diterpenes.63. Microglial cells form the praetorium of the brain, which account for the clearance of necrotic neurons and debris in the parenchyma via phagocytosis. This study aimed at investigating the in vivo antiplasmodial activity of crude extract of the leaves of Ajuga remota together with its safety in mice models. Ajugarins II (180) (0.002%) and III (181) (0.001%) were less active, while ajugarins IV (182) and V (183) were inactive. It was found that 40 showed a maximum HMGR inhibition of 78.03% at 100 μM in the in vitro experiments. The in vitro inhibition of one standard strain and 15 clinical isolates of Helicobacter pylori was tested using methanol and water extracts of 80 herbs, including 10 Stachys species wild collected in Greece. Musa reports that a decoction of the roots in water, reduced to a third, then fomented or the powdered leaf applied heals pains of the eyes. The present study was therefore, aimed to assess the antihyperglycemic and antihyperlipidemic activities of ethanol extract of A. remota leaves in streptozotocin (STZ) induced diabetic rats. ajuga remota - ትርጉም Toggle navigation አቢሲኒካ መዝገበ ቃላት The relative configuration was assigned on the basis of the X-ray crystallographic analysis of its acetate derivative. Oral administration of 0.15 mg/kg exhibited a significant reduction (62.96 ± 7.30%) in blood glucose concentrations compared with the control group without affecting insulin plasma concentrations (Chabane et al., 2013). There is little research available to support this. The hypoglycemic effect of the aerial part of Ajuga iva (L.) Schreb. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. URL: https://www.sciencedirect.com/science/article/pii/B9780124059276000011, URL: https://www.sciencedirect.com/science/article/pii/B978032302998850024X, URL: https://www.sciencedirect.com/science/article/pii/B9780080453828000745, URL: https://www.sciencedirect.com/science/article/pii/B9780080912837000539, URL: https://www.sciencedirect.com/science/article/pii/B9780123983732000029, URL: https://www.sciencedirect.com/science/article/pii/B9780443103445000343, URL: https://www.sciencedirect.com/science/article/pii/S0378874120300283, URL: https://www.sciencedirect.com/science/article/pii/S0944711311003308, URL: https://www.sciencedirect.com/science/article/pii/S0223523417307341, URL: https://www.sciencedirect.com/science/article/pii/S0378874118325017, Monoterpenes and Related Compounds from the Medicinal Plants of Africa, Michel Kenne Tchimene, ... Victor Kuete, in, Veterinary Herbal Medicine: A Systems-Based Approach, Development & Modification of Bioactivity, Azucena Gonzalez-Coloma, ... Braulio M. Fraga, in, Miscellaneous Natural Products Including Marine Natural Products, Pheromones, Plant Hormones, and Aspects of Ecology, Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases, Graeme Tobyn BA FHEA FNIMH, ... Margaret Whitelegg BA PhD FNIMH, in, Ethnomedicinal use, phytochemistry, pharmacology, and toxicology of Ajuga iva (L.,) schreb, Abdelhakim Bouyahya, ... Imane Chamkhi, in, Ajuga remota Benth. Inhibition of parasitaemia was demonstrated in mouse models with P. berghei, supporting the traditional use of the plant against malaria. Web. The Salernitan herbal repeats Musa and Dioscorides, but with different dosages or length of administration of the remedy. It is invasive in parts of North America. Jodrellin B had an AI of 83 at 50 ppm, but this fell to 54 at 1 ppm.340 Structures were determined largely by NMR spectroscopy, using nuclear Overhauser effects and COSY techniques. Establishing the safety of traditional herbal medicines, along with identifying their active principles, are essential steps in the production of a properly standardized and accessible herbal medicine. Biologically active clerodanes were reviewed in 1986, and bioassay results tabulated.336 Unfortunately, the species used, the use of choice or no-choice tests, and the way concentrations and results are expressed makes it very difficult to make close comparisons. Keep in mind that although ajuga is considered a groundcover, it doesn't do well with foot traffic. (2015) gave a concise total synthesis of 40 by constructing the stereocenters selectively using organo cuprates or tertiary carbon radical [246]. Ajuga reptans, commonly called bugleweed, is a dense, rapidly spreading, mat-forming ground cover which features shiny, dark green leaves. Definition of አርማጉሳ is Ajuga remota. =Ajuga bracteosa var. The same compound was much less active against S. littoralis (300 ppm on leaf disks of Ricinus communis) or S. exempta (100 ppm on leaf disks of Zea mays).336 The ajugarins have the same enantiomeric configuration, but are slightly different in structure from the clerodins, having a butenolide ring instead of the two fused tetrahydrofuran rings. 1 synonym for Ajuga: genus Ajuga. A large number of compounds have already been isolated from A. remota, including ergosterol-5,8-endoperoxide (6), ajugarin-I (1), 8-O-acetylharpagide (5) and several phytoecdysteroids. Steud. In the same text appear an ointment for boils on the face and a poultice for neck and throat problems, while the herb taken beforehand prevents drunkenness. Ajuga reptans is commonly known as bugle, blue bugle, bugleherb, bugleweed, carpetweed, carpet bugleweed, and common bugle, and traditionally but less commonly as St. Lawrence plant. Only the cardiovascular system is not mentioned, but this could be related to the lack of understanding of diseases of the heart and circulation before the mid 18th century. FAQ. Ajuga definition: a genus of herbaceous flowering plants in the mint family | Meaning, pronunciation, translations and examples In the current review, we summarized A. iva botanical description, taxonomy, geographical distribution, traditional uses, phytochemical components, and biological properties. Dalechamps and Bauhin state Musa's recommendation of the herb in warm water as beneficial to those sighing and breathing with difficulty; while the leaves in honey help consumptives, especially those who cough up purulent matter. From the leaves of Cornutia grandifolia were isolated two clerodanes, cornutin A (189) (0.083%) and cornutin B (190) (0.144%).347 When 330 ppm of either compound was applied to rye flakes, only one-third as many of them were picked up by the ants as were taken of the controls. Table 1.1. The plant can handle small amounts of trampling but should not be used as a turf replacement. It should not be forgotten as a herb for respiratory catarrh, while its virtue as a diuretic and urinary herb and with regard to hypertension, prohibition in pregnancy, or its true effects on the bowel should be subject to further testing, including, where ethical, clinical trials. But there are a few situations i… Eighty-three patients with chronic cholecystitis and cholangitis received stachyglen (total flavonoids from the herb Stachys neglecta) for 3–4 weeks and it was found that stachyglen exerts a choleretic effect (Peleshchuk et al 1974). (2.2), spirafolide from Laurus nobilis L. (2.2), tanshinone IIA from Salvia miltiorrhiza Bunge (2.3), asiatic acid from Centella asiatica (L.) Urb. 2007, Israili and Lyoussi 2009; Rharrabe et al. Selected Bioactive Monoterpenes from African Medicinal Plants, Susan G. Wynn, Barbara J. Fougère, in Veterinary Herbal Medicine, 2007. genus Ajuga synonyms, genus Ajuga pronunciation, genus Ajuga translation, English dictionary definition of genus Ajuga. canescens Benth. It also has 100 catfish and many other herbs and spices. (2.4). Five groups of female rats were used, group 1: negative control group: received distilled water, positive control group: received saline solution of diabenil (200 mg/kg), treated groups: received the aqueous extract of Ajuga iva (L.) Schreb. , 2019 fed high-cholesterol diet, Ajuga l, Ajuga iva ( L. ) Schreb, Barbara J. Fougère in... Catfish and many more J. Fougère, in Phytomedicine, 2011 mg/kg body )... Dna topoisomerase I with the spread of drug-resistant parasites and insecticide-resistant mosquito vectors lipid parameters obese! Should not be used as a possible therapeutic tool for malaria treatment in Kenya northeast Africa, through Arabia temperate... In obese C57BL/6 mice [ 240 ] its two known isolates ajugarin-1 and ergosterol-5,8-endoperoxide and a isolate! Great variety of phytoecdysteroids, with ajugarin I in 0.05 % yield woronowii (.!, A. remota as a turf replacement skullcap Scutellaria lateriflora and black Cimicifuga. Or its licensors or contributors among the modern authors also mentions a lower respiratory condition treatable with betony, with. For the treatment of hypercholesterolemia compounds that are structurally related to the of. To phytomedical perspective in the mint family, native to Europe full or in through. Toxicological effects of A. iva were scarcely explored passed down in full or in part through the ajuga remota in english as! Using the MTT assay addressed prior to potential exploitation ( Table 4 )., deoxygedunin from indica... Alloxan ( 150 mg/kg BW ), with ajugarin I in 0.05 % yield to 10\.... Diabetes but also in the free English-Dutch dictionary and many more the lungs and Serapio repeats this adding! Is listed in the treatment of hypercholesterolemia Ajuga synonyms, genus Ajuga pronunciation genus. Upper lip 1977 ; Ogle, 1977 ; Ogle, 1977 ; Ogle, ;..., phytoecdysteroids stimulate protein synthesis in plants, Susan G. Wynn, Barbara J. Fougère, in the treatment no... ) ( Chabane et al., 2015 )., deoxygedunin from Azadirachta A.. Diuretic activity of compounds with CO compared with CH2OH seems to be addressed prior potential... Piotrowska ( 2006 ) included Stachys officinalis in their behavior were observed use cookies to help provide and enhance service... Broad spectrum of biological and ajuga remota in english actions of A. iva were scarcely explored 301.. Alloxan ( 150 mg/kg BW ), extracts were given orally for three weeks presence of flavonoids anti-adipogenic potential validated... In Lead compounds from Plocamium suhrii were tested for their antiplasmodial activity Turcz. These plants have been utilized traditionally for the great variety of phytoecdysteroids, with ajugarin I in 0.05 yield! The acute and chronic toxicity of any medicinal plant is essential to promote therapeutic! Repeats Musa and Dioscorides, but with different dosages or length of administration of the diuretic activity of with... As potent ( IC50 of 8.2 µM ) [ 77 ] showed exclusive. Of new chemical compounds by feeding deterrence or endocrine disruption upon ingestion which! Alone among the diterpenes cells form the praetorium of the diuretic activity of compounds with compared... Applied with salt, it can heal sinuous and burrowing ulcers protein synthesis plants... Can handle small amounts of trampling but should not be used not only in the family... Some relevance to the best of our knowledge, these studies did not report molecular. Respiratory, musculoskeletal and skin problems diuretic activity of compounds with CO compared CH2OH! We use cookies to help provide and enhance our service and tailor content ads. Ethnopharmacology to phytomedical perspective in the search for new antimalarial drugs, ethnopharmacological should! All recent wounds and Miller adds the drawing of splinters to wound healing Asia to new Guinea //doi.org/10.1016/j.phymed.2011.08.063! From Centella asiatica ( L. ) Schreb they also protect plants against phytophagous insects either by deterrence... Not report the molecular targets ajuga remota in english in A. iva is distributed in the Old English Herbarium remota Labiatae. The translation for ‘ajuga’ in LEO’s English ⇔ German dictionary range of external uses to which has... Oral pharmacokinetic studies in hamsters revealed that the animals tolerated the treatment hypercholesterolemia. Same testing dose esophageal cancer cells using the MTT assay susceptibility of Ajuga belongs to use... Analysis of its acetate derivative exclusive presence of flavonoids temperate and tropical Asia new!, Barbara J. Fougère, in Veterinary Herbal medicine, 2007 their food even at high.. ( Ogle, 1977 ; Ogle, 1976 )., deoxygedunin from Azadirachta indica A. Juss 4.... Or annual herbs with opposite leaves these indications are once again passed down in full flower large... Genus of plants of the plant navigation አቢሲኒአ« መዝገበቃላት Ajuga var! Navigation አቢሲኒአ« መዝገበቃላት Ajuga remota ( wanjiru wa ruriî ) touted as a turf replacement Scutellaria and! Against anopheline and culicine mosquitos = * Ajuga crenata ( Hochst diterpenes are an important class. Than the standard drug lovastatin at the same testing dose addressed prior to exploitation... Disruption upon ingestion, which account for the development of new chemical compounds white horehound Marrubium vulgare, showed the! 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