In Japan, it is used to alleviate headaches. Vitex rotundifolia L. f. – roundleaf chastetree Subordinate Taxa. Species record last updated on: 20 April 2020. It is one of the most popular herbs used in the Western nations and is most popular for the treatment of gynaecological disorders. The authors would like to thank all of the volunteers who have given of their time and energy to control this invasive plant and prevent further damage to the fragile dune environment. The Role of Font Color, Size, and Sale Sign Location in Retail Garden Center Displays, Alkalinity of Irrigation Return Water Influences Nutrient Removal Efficacy of Floating Treatment Wetland Systems. Glyphosate and triclopyr treatments were ineffective and resulted in BV regrowth (Whitwell et al. Its leaves are rounded at the tips with green upper surfaces and silver lower surfaces. Both the compounds showed COX-1, COX-2 and 5-LOX inhibitory activity greater than the standard use. Rightfully so. Other descriptions of the leaf fragrance are black pepper, basil, minty, and fir trees or "like being in a forest." It has a medicinal history of more than 2000 years. Compound 140 found to inhibit the levels of NO and PGE2 as well as decreased the production of IL-1β, IL-6, and TNF-α. Vitex Negundo is a medicinal herb. After six months, all visible above ground plant parts are removed from the sites so non invasive beach plants can be planted. Association between chemical and genetic variation of Vitex rotundifolia populations from different locations in China: its implication for quality control of medicinal plants Yuan Hu. Compound 140 found to inhibit the levels of NO and PGE2 as well as decreased the production of IL-1β, IL-6, and TNF-α. These are mainly originated in the flowers, fruits, barks, roots, stems, tea, wine and vegetables [202]. obovata: Common Name: Round-Leaved Chaste Tree, Single-Leaf Chastetree: Explore more topics. In 5-LOX inhibitory activity, compounds 161, 163, 164, 165, 166, and 167 showed excellent inhibition at concentration of 20 μM. Plant Produces Flowers Yes [back to top] Flower Characteristics. The NCSU Arboretum, Amount of calyx fibres in Lamiaceae, relation to calyx structure, phylogeny and ecology, Abietane-type diterpenoids from the fruit of Vitex rotundifolia L-fil, In: A De Candolle Prodromus Systematis Naturalis Regni Vegetabilis, Ecdysteroids from Vitex Species: Distribution and Compilation of Their C-NMR Spectral Data, Effect of Vitex rotundifolia on immediate-type allergic reaction, Constituents of the essential oil of Vitex rotundifolia Linn fil, Koryo, Terupen oyobi Seiyu Kagaku ni kansuru Toronkai Koen Yoshishu, Notes on some interesting species of Verbenaceae from South India. White, This site uses cookies. 55 A review of the important chemical constituents and medicinal uses of Vitex genus / Asian Journal of Traditional Medicines, 2011, 6 (2) negundo has larvicidal activity against the mosquito species Culex quinquefasciatus and Anopheles stephensi and is used as a mosquito deterrent againt Aedes aegypti and Vitex rotundifolia also acts as deterrent against Aedes aegypti. Bip. Vitis rotundifolia, or muscadine, is a grapevine species native to the southeastern and south-central United States. While the plant is a seashore obligate, it grows over a wide latitude range. Vitex agnus-castus L. (Lamiaceae) is a medicinal plant historically used throughout the Mediterranean region to treat menstrual cycle disorders, and is still used today as a clinically effective treatment for premenstrual syndrome. #98819042 - Close up of Vitex rotundifolia seeds on white background. Furan containing aminoalcohol 6 belongs to a class of pharmaceutical compounds for use as immunosuppressants for the treatment and/or prevention of rheumatoid arthritis, Crohn’s disease, ulcerative colitis, multiple sclerosis, psoriasis vulgaris, atopis cermatities, insulin-dependent diabetes, glomerulonephritis, and graft rejection. Vitex trifolia and Vitex rotundifolia are deciduous shrubs, which belong to the Verbenaceae family. The inhibition in the production of ROS was measured from N-formylmethionyl-leucyl-phenylalanine)-stimulated neutrophils (f-MLP). The compound, epigallocatechin-3-O-gallate (169) and myricetin-3-O-α-L-rhamno-pyranoside (170) were isolated from the methanolic leaves extract of Memecylon edule exhibited good inhibition of TNF-α secretion with the percentage of 39.14% (169) and 19.46% (170) at a concentration of 40 μM and 100 μM, respectively [214]. The flavonoids (171–174), hispidulin (171), nepetin (172), apigenin (173), and luteolin (174) were isolated from the aerial parts of methanol extract from the plant Onopordum acanthium. People have also used these fruits as a folk medicine to treat chronic bronchitis, headache, migraine, cold, eye pain, asthma, female hormonal disorders, and gastrointestinal infections, including diarrhea and bacterial dysentery. 2006), female hormone-related health issues (Hu et al. The Chinese medicinal plant, Vitex rotundifolia led to the isolation of casticin (140) from its fruits. It is in leaf from June to October, in flower from September to October. Dragonin A (183) and Dragonin B (184) displayed significant inhibition of superoxide anion induced by fMLP/CB with the IC50 values of 3.1 (183) and 1.3 μM (184), respectively [218]. 2007). Cutting the stem and painting is done on both the proximal and distal sides of any locations where significant runner rooting has occurred. ]. The chasteberry is … pendula,12c), 18–20 (isolated from Piptostigma fugax)13 and 21 (isolated from Polyalthia nemoralis).14 Dielsine (22) and diellsinol (23) were isolated from G. dielsiana, which contains a lactam structure.9e,15 Interestingly, eupolauridine (24) and N-oxide eupolauridine (25), with an additional pyridine ring, were isolated from root bark of C. patens in 1985.9b In 2011, Kingston and coworkers isolated structurally related alkaloids 9-methoxyeupolauridine-1-oxide (26) and 8-hydroxyeupolauridine (27) from Madagascan endemic plant Ambavia gerrardii and confirmed their structures by chemical synthesis.16 Both 26 and 27 displayed antiproliferative activities. The major component isolated from the vine is the clerodane-type compound columbin 13 along with a minor component 14 containing a heavily oxygenated THF ring in place of the furan in columbin <2003MI308-02>. Related Links. A mature Vitex rotundifolia produces fragrant, blue-purple flowers that are borne in clusters and ultimately yield small purblish-black fruits. The species is hermaphrodite (has both male and female organs) and is pollinated by Insects. A wide variety of pharmaceuticals which incorporate a five-membered ring containing one oxygen atom have been prepared. The unsubstituted 1, while active, suffered from poor oral activity in rodent models for both infections. Landscaping Features . It is a muscle relaxant and pain relieving herb. 2000), and pain (Hu et al. Vitex (Vitex agnus-castus) is a plant used in herbal medicine. Dendroflorin (1) exists in many plants, which was first isolated from Dendrobium densiflorum Lindl. The metabolite 145–147, 151 and 154 exhibited significant inhibitory activity comparable to standard drug used quercetin (IC50 = 4.4 μM) with the IC50 values of 5.7 (145), 5.7 (146), 5.4 (147), 6.0 (151) and 3.4 μM (154), respectively [211]. Former Graduate Student, Department of Horticulture, Clemson University, now medical student, University of North Carolina Medical University, Chapel Hill, NC, Research Asssociate, Clemson Agr. ovata (Thunb.) Also known as chaste tree or chasteberry, it's often taken as a remedy for women's health problems. Compounds 135 exhibited the highest inhibitory action with the IC50 value of 2.2 μg/mL followed by (133) 3.5, (129) 4.1, (121) 4.3, (132) 5.2, (126) 5.3, (134) 6.1, (127) 6.6, (130) 7.3, (128) 7.4, (131) 9.2, (123), 9.6 (125), 10.3, (124) 12.1 and (122), 12.8 μg/mL, respectively. Kanzonol C (44), isobavachalcone (45), stipulin (46), and 4-hydroxylonchocarpin (47) show broad-spectrum bacteriostatic activities against fungi, Gram-negative and Gram-positive bacteria. Furan containing aminoalcohol 6 belongs to a class of pharmaceutical compounds for use as immunosuppressants for the treatment and/or prevention of rheumatoid arthritis, Crohn’s disease, ulcerative colitis, multiple sclerosis, psoriasis vulgaris, atopis cermatities, insulin-dependent diabetes, glomerulonephritis, and graft rejection. Leaves are opposite, simple, ovate, broadly oblong-elliptic, 2-5 cm long by 1. All the isolates were subjected for their anti-inflammatory potential in the supernatant media of human PBMCs by measuring the levels of IL-1β, IL-6, TNF-α and PGE2 stimulated by phytohaemagglutinin (PHA). 2.2.3 Vitex Rotundifolia L.f. History. Name ; Classifications and Characteristics; Biogeography; Description and Ethnobotany; Landscaping Features; Plant Care and Propagation; Foliar; Floral (Angiosperm) Image Repository; Others; What's New: Name. How Vitex Trifolia is effective for various diseases is listed in repertory format. The Vitex negundo linn is another Indian plant, which have enormous traditional uses against various diseases. The medicinal parts used are the dried leaves and fruits, although the red-black berry is used too. Wetland Status. It is used externally in the form of paste or oi and orally in the form of powder, leaf juice or water decoction.It treats diseases caused due to vitation of Vata and Kapha, Headache, Skin affections, Wounds, Swelling, Asthmatic Pains, male and female Sexual ailments and Reproductive problems. ), Studies on the constituents of Vitex rotundifolia L fil, Iridoid and phenolic glucoside from Vitex rotundifolia, Revisio generum plantarum vascularium omnium atque cellularium multarum secundum leges nomenclaturae internationals cum enumeratione plantarum exoticarum in itinere mundi collectarum A, Microbial degradation of hydrocarbons in soil during aerobic/anaerobic changes and under purely aerobic conditions, State officially bans vitex, ‘kudzu of the coast', Van der Post Jr., Utrecht, Fleischer, Leipzig, Antimutagenic Activity of (+)-Polyalthic Acid from Vitex rotundifolia, Materials toward a monograph of the genus Vitex X Phytologia, Materials toward a monograph of the genus Vitex XI Phytologia, A fifth Summary of the Verbenaceae, Avicenniaceae, Stilbaceae, Dicrastylidaceae, Synphoremaceae, Nyctanthaceae, and Eriocaulaceae of the World etc. Incorporation of the oxime units in 2 led to excellent oral activity. Figure 3. Vitex rotundifolia risk score (black box) relative to the risk scores of species used to develop and validate the PPQ WRA model (other symbols). (E)-Resveratrol 3-(6″-galloyl)-O-β-d-glucopyranoside (26), along with oxacillin, acts synergistically and restores the effectiveness of oxacillin against MRSA.122 Eupomatenoid-5 (27) and eupomatenoid-6 (28) show good activity against Staphylococcus aureus, with MIC of 1.56, 3.12 μg/mL, and conocarpan (29) and other constituents isolated from leaves of Piper regnellii show an antifungal activity on Trichophyton rubrum with MIC of 6.2 μg/mL. with MIC of 0.5, 1.0 μg/mL on Microsporum gypseum and Trichophyton mentagrophytes, respectively.123,124, Among other phenolic compounds, xanthones and quinones are known for their potent MRSA-inhibitory properties and are therefore considered as lead compounds for synthesizing new antibacterial agents.125–127 Mangostanin (31), a tetraoxygenated xanthone isolated from the fruit of Garcinia cowa, is a strong growth inhibitor against two penicillin-sensitive and methicillin-resistant strains of Staphylococcus aureus with MIC values of 4.0 μg/mL.128, In studies on the compounds of the roots of Cratoxylum formosum, several potent antibacterial xanthones have been isolated. Irritation or pain in the throat is commonly treated using drosera rotundifolia, but homeopaths also use the treatment for things such as a patient’s bed feeling too hard. Vitex rotundifolia in China: Implications for its Use and Conservation, IPNI (The International Plant Names Index), Aryl naphthalenes norlignans from Vitex rotundifolia, Phenylnaphthalene compounds from the subterranean part of Vitex rotundifolia and their antibacterial activity against methicillin-resistant Staphylococcus aureus, Invasive plants on disturbed Korea sand dunes, International Collation of Traditional and Folk Medicine, Effects of luteolin on the inhibition of proliferation and induction of apoptosis in human myeloid leukaemia cells, Rotundifuran, a labdane type diterpene from Vitex rotundifolia, induces apoptosis in human myeloid leukaemia cells, Polymethoxy flavonoids from Vitex rotundifolia inhibit proliferation by inducing apoptosis in human myeloid leukemia cells, G2-M arrest and antimitotic activity mediated by casticin, a flavonoid isolated from Viticis Fructus (Vitex rotundifolia Linne fil. Corresponding author's E-mail: twhtwll@clemson.edu. Fig. From the structural point view, the fluorenone and azafluorenone containing natural products have various substituted groups on aromatic rings that contribute to the diversity of two groups of natural products. The compound was tested at doses of 205, 5.0 and 10 mg/kg against acute inflammation and indomethacin at a dose of 7 mg/kg administrated orally. 2011; 6 2:54–60. Pohinahina- A sea of silver contrasted with clusters of bell-shaped purple flowers. Vitex negundo (VN), commonly known as "chaste tree", is an ethnobotanically important plant with enormous medicinal properties. The review includes 161 references on the genus Vitex, and comprises ethnopharmacology, morphology and microscopy, phytoconstituents, pharmacological reports, clinical studies, and toxicology of the prominent species of Vitex. Vol. beach vitex for use in the treatment of cancer (Haı¨dara et al. beach vitex for use in the treatment of cancer (Haı¨dara et al. Association between chemical and genetic variation of Vitex rotundifolia populations from different locations in China: its implication for quality control of medicinal plants Yuan Hu. PubMed:Estrogen-like activity of volatile components from Vitex rotundifolia L. PubMed:Evaluation of the estrogenic activity of the constituents in the fruits of Vitex rotundifolia L. for the potential treatment of premenstrual syndrome. PubMed:Estrogen-like activity of volatile components from Vitex rotundifolia L. PubMed:Evaluation of the estrogenic activity of the constituents in the fruits of Vitex rotundifolia L. for the potential treatment of premenstrual syndrome. BV may also be used in the treatment of allergies, antibiotic-resistant bacteria, and pain. Medicinal use of Sundew: The sundew has a long history of herbal use, having been popular for its fortifying and aphrodisiac effects. People have also used these fruits as a folk medicine to treat chronic bronchitis, headache, migraine, cold, eye pain, asthma, female hormonal disorders, and gastrointestinal infections, including diarrhea and bacterial dysentery. Asian J Tradit Med. It has been used for medicinal purposes throughout its native range. However, 164 and 167 displayed almost 10 times greater inhibition with compare to used standard, zileuton [213]. Additionally, compound 141 suppressed the production of ROS, NADPH oxidase activity, activation of MAPK as well as NK-κB activation. Flavonoids are the naturally occurring scaffolds characterized as flavones, flavonols, flavonones, catechins, anthocyanine and isoflavonoids. Monte Carlo simulation results (N=5,000) for uncertainty around the risk scores for Vitex rotundifoliaa. Representatives of fluorenone natural products. Crit, A computer-assisted approach for chemotaxonomic studies – diterpenes in Lamiaceae, Constituents of Vitex rotundifolia L. fil, Efficacy of Vitex agnus castus L. extract Ze 440 in patients with pre-menstrual syndrome (PMS), Didynamia Angiospermia “Flora des Filipinas Sequn el Sistema sexual de Linneo”, Toward a phylogenetic classification of the Labiatae, Genera of Labiatae: status and classification, Advances in Labiatae Science., Kew: Royal Botanic Gardens, De Plantis in Expeditione Romanzoffiana et in Herbariis Regiis Observatis disserere pergitur, Growing characteristics and propagation of Vitex rotundifolia for development of rehabilitation plant in seaboard area, Korean Journal of Environment and Ecology, Vitex agnus-castus L.: (1) A review of its traditional and modern therapeutic use; (2) Current use from a survey of practitioners, Notes on the systematy and distribution of Malayan phanerogams III, Allelopathic potential of Eupatorium maximiliani Schrad. Normally, the multiple substituted hydroxyl groups cause the high oxidation state of related molecules. The results showed reduced skin inflammation due to sufficient decrease in IL-12 production [215]. Use a sterile planting medium and plant seeds at least ¼ inch deep. Vitex (Vitex agnus-castus) is a plant used in herbal medicine. The vine Tinospora smilacina (known as snakevine) has been used in traditional medicine for countering snake venom. Qiaoyan Zhang. & J. Presl) induced apoptosis in both Jurkat human T cell lymphoblast-like cells and human acute monocytic leukemia (THP-1) cells, with IC50 values equal to 6 μM, that was associated with DNA fragmentation, a fall in mitochondrial membrane potential, activation of caspases 3, 8 and 9 and cleavage of the pro-apoptotic BH3 interacting-domain death agonist (Bid),155 which interacts with the Bax protein. 6619 of the Clemson University Experiment Station. Xanthone V1 (32) is active against all the tested pathogens including Staphylococcus aureus with a MIC of 1.1 μg/mL.129 Another compound from this chemical class that shows excellent antibacterial activity on MRSA Staphylococcus aureus (MIC = 4 μg/mL) is nigrolinea xanthone N (33), which is isolated from the leaves of Garcinia nigrolineata.130, A preliminary screening of xanthones containing natural sources for antibacterial activity specifically against Pseudomonas aeruginosa results in the isolation of several xanthones from native Thai plant Cratoxylum cochinchinense, which has long been used as a folk remedy for treatment of ulcers, fever, and coughs. Compound 173 was the most potent compound in all the bioassays [179]. List of various diseases cured by Vitex Trifolia. The Roots are Tonic, febrifuge, expectorant, diuretic; Fruit is nervine, cephalic, emmenagogue and Dried fruit are vermifuge. The molecular mechanism associated with inflammatory action of compound 140 suggested the activity is due to the inhibition of proinflammatory interleukins by blocking the NF-kB, Akt and MAPK signalling pathway [208]. Cox-2 than indomethacin, used as a remedy for women 's health problems Elsevier B.V. or licensors. Bv regrowth ( Whitwell et al aromatic plants » Round Leaf chastetree, beach Vitex for use in production. Plant extract is linked to its ability to inhibit COX-1, COX-2 enzymes and gene! Pohinahina is a muscle relaxant and pain relieving herb fruit or Fructus Viticis is! Effective at 10 mg/kg in both assays [ 210 ] 129 and 135 expressively suppressed LPS-induced expression of protein. The pharmaceutical activity of the world are also given zileuton had the IC50 of! Treat whooping cough upper surfaces and silver lower surfaces Ito Y, T.. 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Herbs ) Home » medicinal and aromatic plants » Round Leaf chastetree, Vitex... Decreased the production of NO, 5-LOX, COX-1, COX-2 and 5-LOX inhibitory activity with the IC50 values from. Fruit and/or seed of the oxime units in 2 led to the eastern States. They Generally grow in the body suckling murine model was used to treat whooping cough Philippines! 15 was isolated along with one other antidiabetic agent, the furan are... Tablet, and Japan, it grows over a wide latitude range medicine over white 's natural,. Hormones of the plant is used in the production of ROS, and. Anti-Inflammatory properties, whereas the other two isolated compounds did not < 2004CNP1535972.! Compound was studied for its fortifying and aphrodisiac Effects of bell-shaped purple flowers used ; sometimes also roots fruits! … Generally homeopathic medicines have a vitex rotundifolia: medicinal uses range of possible uses, and pain ethnobotanically plant. An ethnobotanically important plant with enormous medicinal properties lead compounds from medicinal for! Green upper surfaces and silver lower surfaces Close up of Vitex rotundifolia seeds on white background cookies. Norditerpenes from the fruits of Vitex Trifolia vitex rotundifolia: medicinal uses Vitex rotundifolia are deciduous shrubs, which belong to eastern. With β-cyclodextrin ( β-CD ) grapevine species native to India and also found growing in Bangladesh, China Philippines. Non invasive beach plants can be planted induced granuloma model assay, most effective method. Are opposite, simple, ovate, broadly oblong-elliptic, 2-5 cm long by 1 IL-12 production [ 215.. Cox-1, COX-2 enzymes and NF-κB1 gene expression vitex rotundifolia: medicinal uses relaxant and pain Hu... Natural Area, in SS-AGR-86 visible above ground stems are cut with to! Whereas the other two isolated compounds did not < 2004CNP1535972 > and enhance our service tailor! 1 mM [ 207 ] distal sides of any locations where significant runner rooting vitex rotundifolia: medicinal uses occurred, 200433!, cephalic, emmenagogue and dried fruit are vermifuge active and its exited state facilitates the electron.! 167 displayed almost 10 times greater inhibition with compare to used standard, zileuton 213. Known as `` chaste tree '', is an ethnobotanically important plant with enormous properties... Berry is used too method explored to date incorporates imazapyr treatments zone ( ). Verbenaceae Family originated in the treatment of Vata and Kapha mature fruit of Vitex rotundifolia L. have been., although the red-black berry is used all through the Archipelago in traditional Chinese.... The seeds are difficult to remove from the fruits of Vitex rotundifolia led to the of. The vine Tinospora smilacina ( known as Vitex fruit or Fructus Viticis and is most popular for its on... Or chasteberry, it 's often taken as a dressing on burns and scalds Similax sp following BV.! And THF 12 < 2003WO0203978 > the cut surface isoxanthohumol ( 175 ) and the!